This study presents a noise-robust closed-loop control strategy for wake flows employing model predictive control. The proposed control framework involves the autonomous offline selection of hyperparameters, eliminating the need for user interaction. To this purpose, Bayesian optimization maximizes the control performance, adapting to external disturbances, plant model inaccuracies and actuation constraints. The noise robustness of the control is achieved through sensor data smoothing based on local polynomial regression. The plant model can be identified through either theoretical formulation or using existing data-driven techniques. In this work we leverage the latter approach, which requires minimal user intervention. The self-tuned control strategy is applied to the control of the wake of the fluidic pinball, with the plant model based solely on aerodynamic force measurements. The closed-loop actuation results in two distinct control mechanisms: boat tailing for drag reduction and stagnation point control for lift stabilization. The control strategy proves to be highly effective even in realistic noise scenarios, despite relying on a plant model based on a reduced number of sensors.